Mihai Pop, professor of computer science and interim director of the University of Maryland Institute for Advanced Computer Studies (UMIACS), directs CHIB activities at the College Park campus. Pop's research interests cover several areas of bioinformatics, primarily related to the development of computational algorithms for analyzing biological data generated through high-throughput experimental techniques, such as sequencing technologies. His research is driven by the belief that there is a strong connection between computational and biological research, computation being not just a simple tool in the hands of biologists, but an integral component of current biological research.

Owen White, professor of public health and epidemiology in the University of Maryland School of Medicine and associate director for bioinformatics at the Institute for Genome Sciences, will direct CHIB activities in Baltimore. White researches huge strings of sequencing data from genomic and biomedical researchers, using computer analyses such as pairwise searches, multiple sequence alignments and other methods in combination with systematic manual evaluation. He has participated in the development of numerous tools for genome comparison, including analysis of plant, fungal, malarial, trypanosomid, Archaeal and Prokaryotic species.

Todd Treangenis the assistant director of the Center for Health-related Informatics and Bioimaging. He is an assistant research scientist with an appointment in the University of Maryland Institute for Advanced Computer Studies (UMIACS). His research interests include efficient multiple genome alignment, phylogenomics, population genetics, meta (zoan,genomic) genome assembly and comparative human genomics/genetics, mostly via NGS data.